Nonmalignant Disorders of Leukocytes
   

Question #1

You are asked to consult on a case involving a 26-year-old man who developed leukocytosis after a motorcycle accident 3 days ago. The patient has multiple fractures of the pelvis and lower extremities, extensive soft-tissue injury, and aspiration pneumonia. His leukocyte count was 35,000 on admission and has subsequently ranged up to 50,000. Currently, the patient is sedated and is on a ventilator. He is being treated with I.V. antibiotics. Physical examination is remarkable for right lower lateral consolidation, ecchymoses of the lower extremities, and the absence of hepatosplenomegaly... Laboratory values are as follows: hemoglobin, 9.5 g/dl; platelets, 140,000/mm33, with 95% neutrophils and bands. No myelocytes or metamyelocytes are noted, and there is no elevation of the basophil or eosinophil count. The leukocyte alkaline phosphatase (LAP) score is 140 µm/L.

Which of the following cannot be the cause of this patient's elevated neutrophil count?

Please choose the single most appropriate answer to the question.
  1. Sepsis
  2. Hemorrhage
  3. Tissue injury
  4. Chronic myeloid leukemia (CML)
  5. Cytokine release